[HTML][HTML] Pancreatic β-Cells in Obesity: EVIDENCE FOR INDUCTION OF FUNCTIONAL, MORPHOLOGIC, AND METABOLIC ABNORMALITIES BY INCREASED LONG …
JL Milburn, H Hirose, YH Lee, Y Nagasawa… - Journal of Biological …, 1995 - ASBMB
To elucidate the mechanism of the basal hyperinsulinemia of obesity, we perfused
pancreata from obese Zucker and lean Wistar rats with substimulatory concentrations of
glucose. Insulin secretion at 4.2 and 5.6 mM glucose was∼ 10 times that of controls,
whereas β-cell volume fraction was increased only 4-fold and DNA per islet 3.5-fold. We
therefore compared glucose usage at 1.4, 2.8, and 5.6 mM. Usage was 8-11.4 times greater
in Zucker islets at 1.4 and 2.8 mM and 4 times greater at 5.6 mM; glucose oxidation at 2.8 …
pancreata from obese Zucker and lean Wistar rats with substimulatory concentrations of
glucose. Insulin secretion at 4.2 and 5.6 mM glucose was∼ 10 times that of controls,
whereas β-cell volume fraction was increased only 4-fold and DNA per islet 3.5-fold. We
therefore compared glucose usage at 1.4, 2.8, and 5.6 mM. Usage was 8-11.4 times greater
in Zucker islets at 1.4 and 2.8 mM and 4 times greater at 5.6 mM; glucose oxidation at 2.8 …
